Category Archives: Impact Investing

TAKE YOUR FOOT OFF THE BAG

John Jonelis

I’ve asked it before, “The way you conduct business—is it meaningful to those left behind?”  Is it? 

I’m here at the Levy Entrepreneurship Group, talking with some of the most brilliant business minds in Chicago.  This group’s been meeting for over 60 years.  It’s the genius of Joe Levy, the prolific entrepreneur, investor, philanthropist—the son of a south Michigan Ave car dealer.  Joe was an endless entrepreneur—constantly learning, constantly experimenting—the quintessential gentleman who gave everybody an at-bat—who spoke quietly but directly and told the truth as he saw it.  He pushed people off the bag“You’re lousy at this.  What are you good at?  Contribute.  Help somebody.”  People found inspiration and hope.  Never a disparaging word about Joe.  “If you don’t have a satisfied customer, you’re compromising your future.”  He was the original automobile mega dealer, angel investor, entrepreneur, and philanthropist.  “God put me on this earth to produce, not to consume.”  Joe Levy is dead at 92.

 

Joe Levy by Anne Elisabeth Hogh

Now I’m sitting with his group—face to face with his family.  We hope to make them understand why we all loved our Saturday morning meetings—why Joe loved them.  The moderator opens the meeting:  “Welcome to the special clubhouse we’re in.  This is a magical place.”  Then we each take turns telling stories to the family:

The Levy Group by Joel Berman

Entrepreneurship Stories

  • Joe told me, “Take your foot off the bag.” It was a constant voice in my head.  Every time I thought, “Should I start this business that I really don’t know much about?” I’d hear that phrase, “Take your foot off the bag.” Sometimes I might take it off a little bit too much.  But I would never be able to start what I’ve done multiple times without that voice in my head and without the support I’ve had from the group.

Take your foot off the bag

  • Joe and I were at the Bryn Mawr Country Club having lunch. Outside the window was this pond with two swans and during the meal, he made a point of the swans, saying, “Aren’t those swans beautiful?”  I said yeah.  Then he did it a second time.  And a third time.  After the meal, we took a walk right up to that pond.  And he said it a fourth time, “Aren’t those swans beautiful?”  I’m like, “Yeah Joe, they are, but what’s your point?”  He said, “Those swans are rental swans.  They’re a business.  I know this guy.  He rents them to all these country clubs.  It’s a beautiful business.”  So the guy puts them out in the spring and he picks them up in the fall and he takes them somewhere to feed them all winter and breed, and then he brings them back again.  It’s got no competition.  Who even would know it exists?  But his point was not only that it was a great business—it’s that it was a simple business in a niche.
  • When Joe found out that I was running my business from my home, he said, “No, you can’t do that.” He said the building next door was empty. He had bought it to store the Levy Center furniture, so we moved in.  That was a big help for us.  A year later, he sat me down.  He said, “Now buy the building.”  The timing was right, so we did.
  • This is the honorary Joe Levy tie. They named a street after him in Evanston where the dealership was.  Following the street dedication, we got ties, and no better day to wear it than today.

The Joe Levy Way Tie – Photo by Rachel Kaberon

  • I recall when they named the street after him. As usual, everybody gave elevator pitches at the start of the meeting.  When it was time for Joe’s introduction, he said, “I’m Joe Levy and now I’m a street.”
  • Twenty years ago Joe wrote a play about internet funerals called Cyber Mourning. It was at the Northlight playhouse in Skokie.
  • When I first met Joe, he asked me what I wanted from him. I knew he had so much to offer a guy like me—a poor immigrant from Greece.  Knowing that people always ask Joe for investment, I thought about his question for a second or so and responded, “Your friendship.”  What I received in return was much more than I could have imagined or hoped for.  He became a friend and a mentor—a man who could address any business issue, and some personal ones as well.  The other thing that we talked about was Joe’s faith—both of our faiths.
  • Not only did Joe teach us the art of being a gentleman—which is very, very hard to do—but he also taught us that entrepreneurship is endless. We took Joe’s words of wisdom, and put them in a placard.”

Plaque presented to the family – Photo by Rachel Kaberon

 The Levy Group

  • The group to me was a way to get working on Saturday without working on Saturday—to get my mind working as an entrepreneur.
  • I remember just 20 years ago coming to the Levy Group and feeling like it was a continuing business education. I call each Saturday a class.  In those classes we talked about business but I also learned about life, loving, giving, and family, and sometimes even death.
  • The ultimate benefit of this group was becoming a ‘Friend of Joe.’ That meant you were part of a group that spanned many a decade and you became aware of the wisdom that came from the experiences shared through the years.
  • I’m having lunch with Joe one day and make a comment to him. And he looks back at me and says, “Do you have a twin brother?”  So I say, “No Joe. Why do you think I have a twin brother?”  He looks at me and says, “Because no one person could be that f’n stupid.”  I use that line all the time today.

Joe in his Flintmobile – Joe Levy Collection

Joe’s Automobiles

  • One Saturday, he brought me into the garage to see his Flintmobile. A full size Flintmobile!
  • He was first at multi-dealerships. Back when Joe was in car dealership, he had eighteen.  People have one, maybe two.  He was the first one to have many.  At one time, he owned 18 dealerships.
  • Car dealerships wouldn’t give a woman the time of day, even if she was with her husband. If she wasn’t with her husband, they took total advantage of her.  Not Joe.  Joe was courteous at all times, and he built an incredible business.  He became the largest Buick dealer in the world.
  • Joe hired a clown for the dealership to entertain the kids. The clown also spied on the spouse.  What she wanted was crucial to the deal.
  • When Buick sold a model called the Wildcat, Joe made sure the Northwestern coaches all drove them.

Joe Levy – Photo by Nathan Mandell

Life

  • One day Joe heard on the radio that they were going to auction off a rare stamp in New York. He gets on a plane, goes to New York, buys the stamp, and before he gets on the plane to come back home, he called Carol and said, “Hey, I’m gonna be late for dinner.”
  • The first thing that will come to my mind when I’m at the racetrack or around horses is Joe Levy. He used to take us there as kids.  He gave us each an envelope with Win, Place, and Show for every single horse.  That was one of Joe’s ways of making sure everybody was a winner.
  • At my daughter’s wedding, my father-in-law took a scissors and snipped away Joe’s tie. Joe thought a moment, then went over and he cut my father-in-law’s tie off.  It was like a Laurel and Hardy thing.  So there they were, the whole evening, with these ties that looked sort of like bow ties without the bows.
  • We had a horse race in the parking lot that included questions about Joe that only the regular group could answer. We had them on silks—sewn numbers on the horses.
  • He gave me an appreciation that family was not just flesh and blood, and giving was not all about money. Time and caring in helping others were way more important in your life, in your learning.
  • Most of the people in cognitive behavior haven’t caught on yet. And all these theorists—they just haven’t caught on to how important kindness and helping and giving are to being able to be an entrepreneur.
  • And if I look back at Joe, what I think about is what he left behind, and that is teaching people how to be good human beings.
  • My dad loved this group. This group was his favorite thing, I think.  All week he looked forward to it—and just so proud of where everybody had come from and gone to.  So, I just—I don’t know what to say—this is just so moving.  So thanks, everybody.

So I ask you, “The way Joe conducted business—is it meaningful to those left behind?” 

 

Chicago Venture Magazine is a publication of Nathaniel Press www.ChicagoVentureMagazine.com Comments and re-posts in full or in part are welcomed and encouraged if accompanied by attribution and a web link. This is not investment advice. We do not guarantee accuracy. Please perform your own due diligence. It’s not our fault if you lose money..Copyright © 2019 John Jonelis – All Rights Reserved
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WHY MILLENNIALS KEEP DUMPING YOU

An Open Letter to Management

by Lisa Earle McLeod

Attracting and keeping top millennial talent is a burning issue for leaders. Millennials are 35% of the workforce. By 2020 they’ll be 46% of the working population.

Some of our most successful clients — organizations like G Adventures, Google, and Hootsuite — are filled with millennials who are on fire for their jobs. Yet many organizations struggle to attract, and retain, top millennial talent.

One of us, Elizabeth, wrote this letter, to share insights about what top-performing millennials want and how leaders can ignite the “energy of a thousand suns.”

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An Open Letter to Management:

You hired us thinking this one might be different; this one might be in it for the long haul. We’re six months in, giving everything we have, then suddenly, we drop a bomb on you. We’re quitting.

We know the stereotypes. Millennials never settle down. We’re drowning in debt for useless degrees. We refuse to put our phone away. We are addicted to lattes even at the expense of our water bill. Our bosses are not wrong about these perceptions. But, pointing to our sometimes irresponsible spending and fear of interpersonal commitment isn’t going to solve your problem. You still need us. We’re the ones who’ve mastered social media, who have the energy of a thousand suns, and who will knock back 5-dollar macchiatos until the job is done perfectly.

I’ve worked in corporate America, administrative offices, advertising agencies, and restaurants. I’ve had bosses ranging from 24 to 64. I’ve had bosses I loved, and bosses I didn’t. I’ve seen my peers quit, and I’ve quit a few times myself. Here’s what’s really behind your millennials’ resignation letter:

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-1- You tolerate low-performance

It’s downright debilitating to a high achiever. I’m working my heart out and every time I look up Donna-Do-Nothing is contemplating how long is too long to take for lunch. I start wondering why leadership tolerates this.

Is that the standard here? No thanks.

Fact: Poor performers have a chilling effect on everyone.

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-2- ROI is not enough for me

I spent Sunday thinking about how I can make a difference to our customers. Now it’s Monday morning, what do I hear? Stock price. Billing. ROI. Suddenly, my Monday power playlist seems useless. I’m sitting in a conference room listening to you drag on about cash flow.

I was making more money bartending in college than I am at this entry-level job. You say I’ll get a raise in a year if the company hits a certain number? So what? I need something to care about today. Talk to me about how we make a difference, not your ROI report.

Fact: Organizations with a purpose bigger than money have a growth rate triple that of their competitors.

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-3- Culture is more than free Panera

Don’t confuse culture with collateral. Yes, I am a cash-strapped millennial who really appreciates free lunch. But I don’t wake up at 6AM every day to play foosball in the break room. I’m not inspired to be more innovative over a Bacon Turkey Bravo.

I need to be surrounded by people who are on fire for what we’re doing. I need a manager who is motivated to push boundaries and think differently. Working in a cool office is really awesome. So is free lunch. But a purposeful culture is more important.

Fact: A culture of purpose drives exponential sales growth

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-4- It’s ok to get personal

Treat me like a number? I’ll return the favor. This job will quickly become nothing more than my rent payment. I’ll start living for Friday and counting down the minutes until 5. After a few months of that, I’ll probably have a drunken epiphany and realize I want more out of my life than this.

Then I’ll prove your assumptions right. 8 months in, I’ll quit and leave. Or worse, I’ll quit and stay, just like Donna-Do-Nothing.

That’s not good for either of us. Here’s what you need to know:

I was raised to believe I could change the world. I’m desperate for you to show me that the work we do here matters, even just a little bit. I’ll make copies, I’ll fetch coffee, I’ll do the grunt work. But I’m not doing it to help you get a new Mercedes.

I’ll give you everything I’ve got, but I need to know it makes a difference to something bigger than your bottom line.

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Signed,

A Millennial

~ ~ ~

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The millennials are telling us what we already know in our hearts to be true. People want to make money; they also want to make a difference. Successful leaders put purpose before profit, and they wind up with teams who drive revenue through the roof.

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This article was co-written with Elizabeth McLeod, a millennial and cum laude graduate of Boston University, and daughter of Lisa Earle McLeod.

Lisa Earle McLeod is the creator of the popular business concept Noble Purpose and author of the bestselling books, SELLING WITH NOBLE PURPOSE and LEADING WITH NOBLE PURPOSE. Lisa is a sales leadership consultant and keynote speaker who helps organizations improve competitive differentiation and emotional engagement. www.mcleodandmore.com

This article previously appeared in Forbes

Image credit: Lisa Earle McLeod

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Also by Lisa Earle McLeod:

Chicago Venture Magazine is a publication of Nathaniel Press www.ChicagoVentureMagazine.com Comments and re-posts in full or in part are welcomed and encouraged if accompanied by attribution and a web link. This is not investment advice. We do not guarantee accuracy. Please perform your own due diligence. It’s not our fault if you lose money.
.Copyright © 2017 John Jonelis – All Rights Reserved
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INQUIRY AND INNOVATION

by John Jonelis

What happens when you invite the community into your high school and send your high school students into the community?

Amazing things! You create a THIRD SPACE in people’s lives.

[Britta McKenna is the Chief Innovation Officer at IMSA.]

Britta – “You have your home and you have your work and you have third spaces in your life where you feel comfortable and find a community. Robert Putnam believed in third spaces. He has a book called Bowling Alone 1. It used to be that bowling leagues were that third space. People at the bar. Cheers. We want IN2 to be that third space in people’s lives.”

“Look at the ceiling. Look at the lights. Do you see the pattern?

IN2 – Symbolism in Architecture

It’s that intersection of outside and inside. Community coming together to make this a real learning laboratory experience. We want to come in and work on real-world problems and opportunities.

“People can bring problems and opportunities to us and say, let’s figure out how we can work together. Like the State of Illinois with the hackathon we just did—finding solutions to childhood lead poisoning.

“Think about all the things kids are doing that are not helping. Here’s a great place. I hope IN2 can be a third space in people’s lives.”

[The grandness of the idea and the imaginative scope hit home, but ask Britta how IN2 will implement it.]

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Innovation

“We can’t stand still. Education—if it’s doing the same thing over and over and over—is not moving ahead—it’s falling behind.

“IN2 is the intersection of what we do at IMSA and the community. We’re partnering with Invest Aurora, the Woman’s Business Development Center, the Fox Valley Entrepreneurship Center—they are all resources to help what we’re doing here grow and scale.

Business Mentor

[Britta anticipates my next question and gets even more specific.]

“We’ve opened up a cohort of LINKubators 2 These are actual startup companies.  We have three working in the space as a pilot.  Our students intern with them and our network can help them grow.  Our MENTORS, our IDEA BARISTAS, our SUBJECT MATTER EXPERTS can all help them grow. 

“Next fall we hope to have ten LINKubator startups working in the IN2 space during the day when the kids are in class. We’re trying to see what we’re good at and get a rhythm to the space.

“So whether it’s somebody in the community with an idea or a problem—whether it’s students that want to accomplish something new—whether it’s mentors from the community coming here to help the next generation of learners—whether it’s subject matter experts helping a non-profit grow—we want IN2 to inspire students and community to go on and be entrepreneurs and develop their ideas.

“Our goal at IN2 is to blend in with IMSA and be that resource for students and community beyond the classroom. That’s what this is all about.”

Student Entrepreneur

Inquiry

“I think one of our signature programs is our STUDENT INQUIRY AND RESEARCH program or SIR. That really distinguishes us because we don’t have class on ‘I-DAYS.’ Those are inquiry days—that happens most every Wednesday. Traditional class shuts down. We have class Monday, Tuesday, Thursday, and Friday.

“‘I-DAYS are meant for independent exploration—inquiry or research. On ‘I-DAYS, student go down to 1871 and other locations to intern for startups. Now, with the new IN2 facility, our students can work with entrepreneurs right here as well. Either way, through the SIR program, they’re doing research with mentors and business teams.”

Sue Fricano & Tami Armstrong

[I’m joined by Sue Fricano—IN2 site coordinator, Tami Armstrong—Director of Public Affairs]

Sue – “MONDAY NIGHT LIVE is an event put on by Dr. Carl Heine each week. He brings in speakers and he develops programs for entrepreneurs.

Carl Heine

“He puts external students on his TALENT board—entrepreneurial students coming in to learn the different stages of building a business and different skills used in building businesses.”

Tami – “A lot of the students here are part of that as well as members of the community that come to learn more about entrepreneurship.”

Sue – “At IN2 we are trying to give them the expertise to go out and make the initial steps of developing.”

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[Betty Hart is the Innovation Center Program Manager.]

Betty – “We have girls in the STEM program, which is a mentoring peer-to-peer program for girls in 6th to 12th grade.  We have events such as IMSA DAY OF CYBER, which focuses on encouraging students to seek cyber security careers.” 

Betty Hart

Betty – “We have TEAM STEM CAFE, which is a network of local high school students who host quarterly events focused on STEM related topics. And we have THINK CAFE, which is a community initiative that invites organizations to come in and pitch a problem or an idea.”

Britta – “Our charges really are this: The first is to be a STEM teaching/learning laboratory for our best and brightest students across the state. Then we have the FUSION programs.3 These are after-school programs at schools, grade 4-8, all around the state. And we also have the charge of educating the educators. We bring the teachers in and give them professional development, which helps them in science and math.”

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Bring Back Socrates

[I pose a thorny question:  Why teach entrepreneurship at such an early age, rather than prepare the students for college or jobs?]

Tami – “What we’re doing is launching the students so when they leave here, they’re prepared. There’s a big demand for ideas and innovation. Innovation is valuable, and very coveted. We’re supplying that to the workforce.

“We’re also launching research. How can students advance the human condition and solve the world’s grandest challenges?

“That’s what comes from IN2—the ability to make very difficult innovations. When you can harness them, bring them to a place like this, and connect the students with business and industry, dream and idea become reality.”

[Suddenly I get it. I asked the wrong question and now realize the goal is really quite straightforward—to encourage students to think for themselves—to let them discover how to learn. IMSA does it the same way it was done almost 2,500 years ago—self-directed inquiry and innovation—the Socratic Method.]

Student Entrepreneur

Possibilities

Britta – “People think we’re just this gifted school for 650 sophomores, juniors, and seniors from around the state, but we’re not. And people think we’re a private school and we’re not—we’re public. We don’t want to be the best-kept secret in Illinois.”

“And we have a student team called IMSA ELEMENT that teaches the lean startup methodology. Build—measure—learn. Students developed a whole curriculum and teach it to each other. We’re entertaining possibilities.”

  • “We need to be open to ideas, be able to move quickly, and say YES.”
  • “And have FAST FAILS.”
  • “And move toward SUCCESS and ITERATE.”

“We’re not afraid to do that here. In a world where you’re dealing with high-caliber students who don’t fail often, failure is a difficult concept. But once they get the hang of it, they actually become quite good at fast fails.”

Entrepreneur with a solution

The 17%

Britta – “We’re not looking for the vast majority to really understand this space, because we can’t hold everybody. But about 17% in the world are innovators. That’s who we’re looking for—that 17%. Once we get a few of those, they bring their networks. Those are the early adopters, innovators, and they see things much earlier.”

Those are the people IN2 was built to serve.

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This is the final article in this series.

Go to Part 1 – THE NAME IS IN2

Go to Part 2 – POWER PITCH

 Go to next series – TOP OF THE LIST

 

References

  1. BOWLING ALONE – Robert Putnam
  2. IN2 Launches LINKubator for Fox Valley Startups
  3. IMSA FUSION

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IN2 Contact Info

Address – 1500 Sullivan Rd. Aurora, IL 60506

Website – https://www.imsa.edu/

Carl Heine – heine@imsa.edu

Britta McKenna – bmckenna@imsa.edu

Tami Armstrong – tarmstrong@imsa.edu

 

Chicago Venture Magazine is a publication of Nathaniel Press www.ChicagoVentureMagazine.com Comments and re-posts in full or in part are welcomed and encouraged if accompanied by attribution and a web link. This is not investment advice. We do not guarantee accuracy. It’s not our fault if you lose money.
.Copyright © 2017 John Jonelis – All Rights Reserved
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CANCER STOPPER

Cancer Treatment from MS Office TEssential Biotechnology –

New Treatment for Hard to Treat Cancer

Jayson Kurfis

A protein, CRR9, serves as a nexus for tumor cell survival. It’s located on the cell surface, making it an accessible drug target. By developing antibodies to the CRR9 protein, Essential Biotechnology has devised a method to kill therapy-resistant tumors. Continue reading

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THIS AIN’T NO LEMONADE STAND

20160402_143634-JAJ TLoop Lonagan—Verbatim

What if y’could combat starvation by producin’ yer own meat ‘n potatoes—and do it right at da local food bank? Hey, I’m lookin’ at a real working prototype here. What about a solution to student debt? Or, maybe fer yer next birthday party, ever’body plays laser tag with drones? Or learns music real fast? Or gets a little help rememberin’ stuff. I can use summa that.

This ain’t no lemonade stand—I’m talkin’ serious business ventures here. One of ‘em launched her company this year and raised $250K in revenue already. Yeah, you heard right—a quarter million bucks. IMG_6636And she’s a high school sophomore! They’s ALL high school students! This is POWER PITCH, ‘n’ we’re at IMSA—the Illinois Math ‘n’ Science Academy. Real smart kids go here. I never seen nothin’ like it—all I remember about high school is gettin’ in trouble all da time.

I sure hope John’s cleanin’ up my language before he prints this stuff.

Editor’s Note—This is a verbatim transcript. It is the policy of this journal to do each writer justice. I might point out that Lonagan doesn’t give himself enough credit. He graduated the University of Chicago with a Masters in Finance.

20160402_143634-JAJ

We got almost 40 teams pitchin’ here, and they’s all real professional-like. One o’ da mentors flew in all the way from Silicon Valley ‘n’ spent days ‘n’ days coachin-up deeze kids. They musta worked their little tails off. DSC_0055Another thing I notice—seems like nowadays, kids wanna do somethin’ good fer da world, insteada da usual greed ‘n’ avarice.

They’s buildin’ a whole wing o’ da school—exclusive fer startups. And today’s winners get thousands in prize money.

Jonelis invited a couple o’ the judges ‘n’ I don’t know why he picked me but I’m glad he did. I mean, c’mon—how can a guy pass up somethin’ like this?

DSC_0052Sixteen of us is tryin’ t’ pick da best o’ da best. Alotta these judges is big-time professional investors I know personal-like, ‘n’ I hear ‘em sayin’ stuff like, “Deeze pitches here is better den downtown.” Sheesh, I feel like a kid in a candy store. I mean, yer lookin’ at da hope o’ tomorrow! And it happens every year!

Just take a glimpse at summa deeze startups. I put ‘em in alphabetic’ order I think. And lemme say thanks t’ Carl Heine who runs dis thing. And Jim Gerry who’s retired but can’t stay away. And Britta McKenna who’s da Chief Innovation Officer. Naturally they’s all PhDs.

20160402_142354-JAJ

Tech Ventures

  • Drone Wars—Having fun with flying laser robots—Max Orr
  • FlashFun—The Personalized Concierge in the palm of your hand—Palak Agarwal
  • Flock—A free and efficient social media platform for easily getting together with your friends—Ben Maher, Timur Javid, Michael Dow, Shrey Patel
  • HeadsUp—A projectable HUD purposed to prevent distracted driving-based accidents by keeping drivers’ eyes up and on the road—Sneha Pathuri, Ian Anderson, Andriy Sheptunov, Xinyu Guan
  • Icosadeck—Icosadeck reinvents the flashcard, making it multi-sided and adding other features to let students note more information, with more organization, and more efficiency—Gunwati Agrawal
  • NoteHub—A Website where students can buy and sell their school notes—Katreena Subramanian, Devan Grover
  • Peanut Butter—Peanut Butter motivates Millennial employees by offering a unique benefit that reduces their student debt—Aneesh Kudaravalli, Tyler StockIMG_6631
  • RemindMe—You shouldn’t have to remind yourself to remember – RemindMe is a smart phone app that uses proven techniques in memory research to help you retain information longer and retrieve it faster—Ahana Narayanan
  • Right Glow—Right Glow is a silicone bathmat that when stepped on glows red, providing the user with a light source that does not cause the temporary blinding sensation associated with turning on a light late at night—Luke Morrical
  • Snowflake—An Automatic, not manual, fridge inventory keeper and recipe recommender—Xinyu Guan, Andriy Sheptunov
  • Vestal—Social platform where you interact with other in Virtual Reality using just a smart phone and a viewer—Isabel Lee
  • XYZone—Improve your pitching accuracy with the only 3D Strike Zone—Hector Correa

Social Ventures

  • AquaFood—A permaculture company proposing aquaponics as a biotechnological solution to combat starvation and environmental problems in your own neighborhood and in the world—Erol IkizIMG_6659
  • Blabl—A mobile application that engages speech impaired children in conversation with a virtual pen-pal—Ayan Agarwal
  • HydroHero—Generate water for the people—George Moe
  • Pass Your Plate—Pass Your Plate helps businesses by taking their waste food and donating it to shelters in the area—Aneesh Kudaravalli, Tyler Stock, Shana Farhang
  • SelfHealth—SelfHealth is a system that puts you in control of your own medical information—Alex Orlov
  • SirenAlert—SirenAlert, is developing a Bluetooth app and signal monitoring hardware to help emergency vehicles avoid traffic collisions and improve response time by alerting even the most distracted drivers, saving lives—John Valin
  • SocialGood—SocialGood translates social media activity into charitable donations utilizing social media activity—Vainius NormantasIMG_6637
  • Thinkubator—Thinkubator is a co-curricular program that challenges students to think & solve pressing community issues, for graduation-required service hours—Sivam Bhatt and Nabeel Rashee
  • The Muzic Academy—It will only take a minuet to learn, but what you learn will last a lifetime—Abinaya Ramakrishnan

Other Ventures

  • AlertIsabella Ginnett, Ashritha Karuturi, Priya Kumar
  • Ask Me 101Rishi Modi, AJ Federici
  • CirclesJulian Litvak
  • FunkyPlantsAkshay Verma
  • InspireEsther Mathew, Amahlia SuDSC_0036
  • LinguLucy Liu and Rebecca Xun
  • LoopNicholas Rodriguez, Isaac Adorno
  • LynxAllAnkit Agarwal, Sweta Kotha
  • MusiWebMaya Wlodarczyk
  • OmNoteClaudia Zhu
  • PoweritForwardShriya Chennuru, Harshita Degala
  • SlipTieSushil Upadhyayula, Pranav Upadhyayula
  • Spatio StationMarc Peczka
  • SugarSmart!Aimee van den Berg, Kate Rabideau, Pranav Narayanan, Abhay Gupta
  • The CommunityMadison Mack

Also read – RAW TALENT

Contact IMSA’s Britta McKenna at bmckenna@imsa.edu

Photo credits – IMSA & John Jonelis

Chicago Venture Magazine is a publication of Nathaniel Press www.ChicagoVentureMagazine.com Comments and re-posts in full or in part are welcomed and encouraged if accompanied by attribution and a web link. This is not investment advice. We do not guarantee accuracy. It’s not our fault if you lose money.

.Copyright © 2016 John Jonelis – All Rights Reserved

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BLOOD CENTER

Jayson Kurfis

7-0_immunology_nkcell_TAdapted from News From Heartland

Since the early 1900s, the state of Wisconsin has been at the forefront of commercializing great scientific discoveries. With the renewal of a 5-year, $20 million competitive grant to the Clinical and Translational Science Institute (CTSI), funding will go to a consortium of eight regional organizations whose mission is to advance the health of the community through research and discovery. This will offer significant opportunities for investment. The article focuses on the innovations of one of those groups, BloodCenter of Wisconsin.

Blood-Center improves outcomes for people with blood-related disorders. This includes providing educational services to the medical community, while providing 70% of the blood used in the State of Wisconsin. Beyond these valuable services, BloodCenter has a substantial research effort focused on finding cures. In fact, from a research standpoint, it is well-known and extremely active in the peer review process, and has produced over 3000 research publications. The primary focus of Blood Center’s Medical Science Institute is research in the areas of transfusion medicine, hematology, bleeding and clotting disorders.

Of particular interest to investors is the work of its technology transfer office. The organization holds over one hundred issued patents in the US and abroad. The strong patent and license activity helps “bridge the gap” from basic research to commercialization. The institutions most successful spin-off, GTI Diagnostics currently owned by Immucor, is focused on blood-based diagnostics. The company sold to a private equity firm in 2008 for approximately $20 million dollars and sold two years later to Gen Probe for $53 million.

Since the group was sold off by BloodCenter to a private equity firm, the global diagnostics market has experienced significant growth, which is expected to continue. BloodCenter continues to innovate within the diagnostics space.

 

Growth Curve

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Von Willebrand Disease Screening Assay

Von Willebrand Disease is the most common hereditary coagulation condition in humans; it has a variety of subtypes; however, Type 1 is the most common. The disease arises from a qualitative or quantitative deficiency of Von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.

Market Size

VonWillebrand disease (VWD) affects an estimated 1% of the world’s population and impacts both males and females in equal proportion.

Technology Benefits

  • Uses standard ELISA or a scalable bead-based format allowing high throughput screening
  • No platelets used as an assay reagent leading to lower reagent and QC cost
  • No ristocetin used, which leads to reduced costs and efficiencies
  • Rapid and more accurate diagnosis of some sub-types of VWD

Patent Status

US8865415, US8318444, US8163496

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Improved Heparin Induced Thrombocytopenia (HIT) assay

6-1_tm_aeo_115x115Heparin-induced thrombocytopenia (HIT) is the development of a low platelet count after administration of the commonly used anticoagulant heparin. HIT causing antibodies can, in some patients, activate platelets leading additionally to thrombosis or clotting events causing stroke, loss of limb, or death.

Currently, the ELISA, enzyme-linked immunosorbent assay, blood test is aimed at detecting antibodies against heparin-PF4 complexes. This test detects all circulating antibodies that bind heparin-PF4 complexes, and has a high false positive rate. Therefore, those with a positive result are tested further with a functional assay called the serotonin release assay (SRA test), which is difficult to perform. An improved HIT assay represents a significant advancement.

Market Size

In 2014, heparin had a market size of 8.2 billion dollars. Heparin is given to millions of patients annually. About 5% are at risk for HIT. Any patient receiving heparin who develops unexplained thrombocytopenia should be tested for antibody.

Technology Benefits

  • Sensitivity and specificity measures are the same or better than current gold-standard SRA
  • Potential for improved reproducibility
  • Lower turn-around time and costs
  • Non-radioactive and lower complexity laboratory method

Patent Status:

PCT application was filed in November of 2014

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6-0_pharmtrials_115x115

Numerous other technologies are currently being developed at the Blood Center of Wisconsin. For more information, please contact Laura Savatski at Laura.Savatski@bcw.edu.

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Sources

(1) http://www.prnewswire.com/news-releases/gen-probe-acquires-gti-diagnostics-for-53-million-in-cash-111991764.html

(2) https://www.alliedmarketresearch.com/DNA-diagnostics-market

(3) http://www.prnewswire.com/news-releases/blood-screening-market—global-market-research-2015-2019-with-abbott-diagnostics-biomerieux-grifols–roche-diagnostics-dominating-300170181.html

(4) http://www.pmlive.com/top_pharma_list/Top_50_pharmaceutical_products_by_global_sales

(5) https://www.alliedmarketresearch.com/ivd-in-vitro-diagnostics-market

(6) http://corporate.morningstar.com/us/html/pdf/Healthcare-Observer-Jan-2013.pdf

(7) http://www.transparencymarketresearch.com/heparin-market.html

(8) http://www.xconomy.com/san-diego/2010/12/16/gen-probe-pays-53m-for-gti-diagnostics/

 

Copyright © 2016 Jayson Kurfis

Graphics – Blood Center of Wisconsin bcw.edu

This is an excerpt from an article that first appeared in NEWS FROM HEARTLAND

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Chicago Venture Magazine is a publication of Nathaniel Press www.ChicagoVentureMagazine.com Comments and re-posts in full or in part are welcomed and encouraged if accompanied by attribution and a web link. This is not investment advice. We do not guarantee accuracy. It’s not our fault if you lose money.

.Copyright © 2016 John Jonelis – All Rights Reserved

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MAY THE FOREST BE WITH YOU

Neil Kane TUsing Whole Trees in Building Construction

Neil Kane

If there was ever a way to combine high tech and high touch as John Naisbitt stated in High Tech, High Touch, his 1999 follow-up to his 1982 bestseller Megatrends, “embracing technology that preserves our humanness”, WholeTrees Architecture & Structures of Madison, Wisconsin epitomizes it. WholeTrees is an innovative company that has hit it out of the park in terms of innovating on technology while providing a substantial impact return, all while having one of the most gorgeous and aesthetically pleasing product lines you’ll ever see.

WholeTrees uses trees as turn-key structural systems in commercial and residential building construction. Until you see the photos, however, the description doesn’t do justice to the warmth of their offering.

Building-Interior 1000

Myrick Hixon EcoPark, LaCrosse, Wisconsin

The co-founding team of Roald Gundersen AIA, an architect, and Amelia Baxter, in partnership with the Forest Products Laboratory of the U.S. Department of Agriculture (USDA) Forest Service, have developed a process that allows them to cost-effectively grade, engineer and manufacture the small trees removed from routine forest thinning (called small diameter round-timber), and use the timber as patented trusses, beams and joists in building construction. In doing so they turn forest waste into a sustainable and high value building material.

Round timber is an abundant and renewable resource. The timber is sustainably harvested then dried and treated to protect against shrinkage and pests. Pound for pound as strong as steel in tension, unmilled timber requires less than two percent of the energy of concrete and steel materials for processing and transportation.

IMG_1094-1000

YMCA lobby, Dallas, Texas, 2015

“We are positioned to occupy a large niche in the approximately $13 billion U.S. sustainable structural systems market,” says Amelia Baxter, president. WholeTrees is a woman-owned business with pending Woman-Owned Business Enterprise (WBE) certification.

Last week they announced a $1.8 million debt and equity financing from investors who characterize themselves as “impact investors”. Impact investors seek environmental and social returns in addition to financial returns. WholeTrees also receives on-going grant support through the USDA’s Small Business Innovation Research (SBIR) program.

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Neil Kane Portrait

Neil Kane writes about leadership and turning innovations into businesses.

This article first appeared in Forbes.com

and News from Heartland

Copyright © 2016 Neil Kane

Photographs: WholeTrees Architecture & Structures & Neil Kane

 

Chicago Venture Magazine is a publication of Nathaniel Press www.ChicagoVentureMagazine.com Comments and re-posts in full or in part are welcomed and encouraged if accompanied by attribution and a web link. This is not investment advice. We do not guarantee accuracy. It’s not our fault if you lose money.

.Copyright © 2016 John Jonelis – All Rights Reserved

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